Based on recent research, black raspberries have shown significant potential in cancer prevention and treatment.
A study found that volatile extracts from black raspberries have an anti-proliferative effect on human lung adenocarcinoma cells, partially through inducing apoptosis1.
Another research showed the extract's ability to inhibit regulatory T-cell activity, promoting cytotoxic CD8 T-cell activity at tumor sites during head and neck squamous cell carcinoma2.
Black raspberry anthocyanins (BRAs) improved blood glucose, lipid metabolism, and retinopathy in diabetic rats, significantly improving morphological changes and apoptosis of retinal pigment epithelial cells3.
Unripe Rubus occidentalis (black raspberry) was found to have more significant anti-cancer effects than fully ripe black raspberries on gastric cancer cells4.
In another study, berry volatile extracts from blackberries, black raspberries, and blueberries had an anti-proliferative effect on non-small lung cancer cells5.
Moreover, it has been demonstrated that a diet containing freeze-dried black raspberries inhibits the development of chemically induced cancer in the rat esophagus6. The same study also highlighted the antioxidant properties of black raspberries and their ability to induce keratinocyte apoptosis7.
Finally, freeze-dried black raspberry powder has been found to exert anti-cancer effects on genes associated with proliferation, apoptosis, and angiogenesis8.
In conclusion, black raspberries contain various anti-cancer compounds and micronutrients that can increase the beneficial effects of breast cancer treatments9.
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1Huang, Y., Zhang, Y., Zhang, X., Shi, Y., & Qiao, L. (2018). Volatile organic compounds of black raspberry (Rubus occidentalis) inhibit the growth of A549 human lung cancer cells. Food & function, 9(12), 6412-6424.
Wang, L. S., Kuo, C. T., Stoner, K., Yearsley, M., Oshima, K., Yu, J., ... & Huang, T. H. M. (2017). Dietary black raspberries modulate DNA methylation in dextran sodium sulfate (DSS)-induced ulcerative colitis. Carcinogenesis, 38(12), 1178-1185.
Li, Y., Wu, Y., Yao, X., Hao, F., Yu, C., Bao, Y., ... & Sun, X. (2018). Black raspberry extract and fractions contain angiogenesis inhibitors. Journal of agricultural and food chemistry, 66(25), 6293-6301.
Kim, B., Ku, C. S., Pham, T. X., Park, Y., Martin, D. A., Xie, L., ... & Lee, J. (2013). Aronia melanocarpa (chokeberry) polyphenol–rich extract improves antioxidant function and reduces total plasma cholesterol in apolipoprotein E knockout mice. Nutrition Research, 33(5), 406-413.
Jeong, J. B., & Jeong, H. J. (2010). Rubus coreanus Miquel extract causes apoptosis of doxorubicin-resistant NCI/ADR-RES ovarian cancer cells via JNK phosphorylation. Molecular medicine reports, 3(4), 645-651.
Kresty, L. A., Morse, M. A., Morgan, C., Carlton, P. S., Lu, J., Gupta, A., ... & Stoner, G. D. (2001). Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries. Cancer research, 61(16), 6112-6119.
Harris, G. K., Gupta, A., Nines, R. G., Kresty, L. A., Habib, S. G., Frankel, W. L., ... & Stoner, G. D. (2001). Effects of lyophilized black raspberries on azoxymethane-induced colon cancer and 8-hydroxy-2'-deoxyguanosine levels in the Fischer 344 rat. Nutrition and cancer, 40(2), 125-133.
Mallery, S. R., Budendorf, D. E., Larsen, M. P., Pei, P., Tong, M., Holpuch, A. S., ... & Stoner, G. D. (2011). Effects of human oral mucosal tissue, saliva, and oral microflora on intraoral metabolism and bioactivation of black raspberry anthocyanins. Cancer Prevention Research, 4(8), 1209-1221.
Wang, L. S., Arnold, M., Huang, Y. W., Sardo, C., Seguin, C., Martin, E., ... & Huang, T. H. (2011). Modulation of genetic and epigenetic biomarkers of colorectal cancer in humans by black raspberries: a phase I pilot study. Clinical Cancer Research, 17(3), 598-610.
